• Fitri Rahmi Fadhilah Institut Kesehatan Rajawali
  • Firman Rezaldi Universitas Mathla'ul Anwar Banten
  • Muhammad Fariz Fadhillah Universitas Mathla'ul Anwar Banten
  • Muhammad Faizal Fathurohim Universitas Padjajaran Bandung
  • Usman Setiawan Universitas Mathla'ul Anwar Banten


Biotechnology, Vaccines, Healthy, Halal


Biotechnology is the application of the branch of biology that involves other applied sciences in applying the principles of living things to produce goods and services, both conventional and modern. The application of biotechnological methods that are increasingly rapid, especially in the health and pharmaceutical fields, has a lot to fight for, especially in developing vaccines with healthy and halal criteria according to the biotech perspective. Halal status in the world of modern science has become a global issue, including the use of peptide-based vaccines. The results of the review show that a healthy and halal vaccine certainly has criteria, namely that it is safe to use, does not produce allergic reactions in the human body such as those made from horses or pigs. PCR is one of the molecular biology methods in the study of modern biotechnological methods which has a high level of sensitivity in detecting the content of pig DNA in various products, both medicinal and food.


Atma. Y., Taufik. M., dan Seftiono. H. 2018. Identifikasi Resiko Titik Kritis Kehalalan

Produk Pangan: Studi Produk Bioteknologi. Jurnal Teknologi Vol 10, No 1. Hal 61 – 66.

Borysiewicz LK, Fiander A, Nimako M, et al. 1996. A recombinant vaccinia virus encoding

human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for

cervical cancer. Lancet; 347: 1523-7.

Brown D.R., Fan L., Jones J., and Bryan J., 1995. Colocalization of Human Papillomavirus Type 11 E1^E4 and L1 Proteins in Human Foreskin Smoking. J. Nat. Canc. Inst. Monogr. 31: 20 – 28.

Cahyaningsih, D., Latif, H., dan Sudarnika, E. 2019. Identifikasi Penambahan Daging Babi

pada Pangan Berbahan Dasar Daging Sapi Menggunakan ELISA dan qPCR.

Acta Veterinaria Indonesia, Vol 7, No. 2.

De Gruijl TD, van den Eertwegh AJ, Pinedo HM, Scheper RJ. 2008. Whole-cell cancer

vaccination: from autologous to allogeneic tumor-and dendritic cell based vaccines.

Cancer Immunol Immunother. 57: 1569-77.

Fatchiyah, Arumingtyas L, Widyarti S, Rahayu S, 2011. Biologi Molekular. Jakarta:


Gomez-Gutierrez JG, Elpek KG, Montes de Oca-Luna R, Shirwan H, Sam Zhou H,

McMasters KM. 2007. Vaccination with an adenoviral vector expressing calreticulin-

human papillomavirus 16 E7 fusion protein eradicates E7 expressing established

tumors in mice. Cancer Immunol Immunother. 56: 997-1007.

Johnson AM, Merlini G, Sheldon J & Ichihara K. 2007. Clinical indications for plasma

protein assays: transthyretin (prealbumin) in inflammation and malnutrition1)

International Federation of Clinical Chemistry and Laboratory Medicine

(IFCC) IFCC Scientific Division Committee on Plasma Proteins (CPP). Clin Chem

Lab Med 2007;45(3):419–426. by Walter de Gruyter . Berlin . New York. DOI


Indrova M, Bieblova J, Jandlova T, Vonka V, Pajtasz-Piasecka E, Reinis M. 2006

Chemotherapy, IL-12 gene therapy and combined adjuvant therapy of HPV 16-

associated MHC class I- proficient and-deficient tumours. Int J Oncol. 28: 253-9.

Kim D, Gambhira R, Karanam B, Monie A, Hung CF, Roden R, Wu TC. 2008.

Generation and characterization of a preventive and therapeutic HPV D NA vaccine.

Vaccine. 26: 351-60.

Kim TW, Hung CF, Juang J, He L, Hardwick JM, Wu TC. 2004. Enhancement of

suicidal DNA vaccine potency by delaying suicidal DNA-induced cell death.

Gene Ther. 11: 336-42.

Kurniadi, M dan Frediansyah, A. 2016. Perspektif Halal Produk Pangan Berbasis Bioproses

Mikrobia. Jurnal Reaktor Vol 16, No. 3.

Liao CW, Chen CA, Lee CN, et al, 2005. Fusion protein vaccine by domains of

bacterial exotoxin linked with a tumor antigen generates potent immunologic

responses and antitumor effects. Cancer Res. 65: 9089-98

Ma B, Xu Y, Fu-Hung C, Wu TC. 2010. HPV and Therapeutic Vaccines: Where are We in 2010? Current Cancer Therapy Reviews. 6: 81-103

Novel S.S, Safitri R, Hatijanto SH, Nuswantara S, Perbandingan Beberapa Metode Molekuler dalam Uji DNA HPV (Human Papillomavirus). 2011. CDK 186 (38):5

Parikesit, A. A., & Anurogo, D. (2017). Pemanfaatan bioinformatika dalam bidang

pertanian dan kesehatan. Review. Vol 85 (2), 105 – 115.


Radji M. 2009. Vaksin DNA: Vaksin Generasi Keempat. Majalah Ilmu Kefarmasian

Vol.VI, No. 1:28 – 37.

Sagara B. 2013. Industri Pangan Halal. e-book.

Santin AD, Bellone S, Palmieri M, et al. 2008. Human papillomavirus type 16 and 18

E7-pulsed dendritic cell vaccination of stage IB or IIA cervical cancer

patients: a phase I escalating-dose trial. J Virol. 82: 1968-79.

Setiawan, R. B. (2012). Efektivitas Vaksin Dari Bakteri Mycobacterium Fortuitum Yang

Diinaktivasi Dengan Pemanasan Untuk Pencegahan Penyakit Mycobacteriosis Pada

Ikan Gurami (Osphronemus Gouramy). Jurnal Perikanan Kelautan, 3(1).

Sewell DA, Douven D, Pan ZK, Rodriguez A, Paterson Y. 2004. Regression of HPV-

positive tumors treated with a new Listeria monocytogenes vaccine.

Arch Otolaryngol Head Neck Surg. 130: 92-7.

Sewell DA, Pan ZK, Paterson Y. 2008. Listeria-based HPV-16 E7 vaccines limit

autochthonous tumor growth in a transgenic mouse model for HPV-16

transformed tumors. Vaccine. 26: 5315-20.

Steller MA, Gurski KJ, Murakami M, et al. 1998. Cell-mediated immunological responses

in cervical and vaginal cancer patients immunized with a lipidated epitope of human

papillomavirus type 16 E7. Clin Cancer Res. 4: 2103-9.

Surat Keputusan Lembaga Pengkajian Pangan, Obat-obatan dan Kosmetika Majelis Ulama

Indonesia Nomor: SK49/Dir/LPPOM MUI/XII/14 Tentang Kebijakan Analisa

Laboratorium.1 – 4.

Tillman BW, Hayes TL, DeGruijl TD, Douglas JT, Curiel DT. 2000. Adenoviral vectors

targeted to CD40 enhance the efficacy of dendritic cell- based vaccination

against human papillomavirus 16-induced tumor cells in a murine model.

Cancer Res. 60: 5456-63.

Wasilah, U., Rohimah, S., & Su’udi, M.(2019).Perkembangan Bioteknologi di Indonesia.

Rekayasa, 12(2), 85-90.

Yusuf. Z. K. 2010. Polymerase Chain Reaction. Saintek Vol. 5, No. 6. Hal 1-6.




How to Cite

Fitri Rahmi Fadhilah, Firman Rezaldi, Muhammad Fariz Fadhillah, Muhammad Faizal Fathurohim, & Usman Setiawan. (2021). NARRATIVE REVIEW: METODE ANALISIS PRODUK VAKSIN YANG AMAN DAN HALAL BERDASARKAN PERSPEKTIF BIOTEKNOLOGI. IJMA: INTERNATIONAL JOURNAL MATHLA’UL ANWAR OF HALAL ISSUES, 1(1), 64–80. Retrieved from